Pregnancy Outcomes after Successful intracytoplasmic sperm injection in Women with Recurrent Abortions
1.Ardi F. Sutanto,
2.Pratama G. Arman,
3. Akbar L. Hafiz
1.M.D., PhD, Gynecology and Obstetrics Department , Indonesian Society for Assisted Reproductive Technology (ISART), Center for Reproductive Health, Universitas Airlangga, Surabaya
2. M.D., PhD in Reproductive Biology, Indonesian Society for Reproductive Medicine (ISRM), Fertility Clinic, Universitas Indonesia, Jakarta
3. M.D., M.Sc. Clinical Embryology, Indonesian Fertility and Sterility Society (IFSS), Reproductive Medicine Center, Universitas Gadjah Mada, Yogyakarta
Abstract
Background: Recurrent pregnancy loss is a challenging clinical condition with significant emotional and physical burden. Assisted reproductive technologies, such as ICSI, have provided new options for these patients, but the long-term pregnancy outcomes remain unclear.
Objective: To evaluate pregnancy outcomes in women with a history of recurrent abortions who achieved successful pregnancy through intracytoplasmic sperm injection (ICSI).
Methods: This retrospective cohort study included women with a history of ≥3 consecutive spontaneous abortions who underwent ICSI treatment and achieved a viable pregnancy. Pregnancy outcomes, including live birth rate, preterm birth, low birth weight, and pregnancy complications, were analyzed and compared to a control group of women without a history of recurrent abortions who also underwent successful ICSI.
Results: A total of 128 women with recurrent abortions and 218 controls were included. The live birth rate was similar between the two groups (72.7% vs. 76.1%, p=0.45). However, women with a history of recurrent abortions had a significantly higher rate of preterm birth (<37 weeks, 26.6% vs. 12.8%, p=0.002) and low birth weight (<2500g, 21.9% vs. 9.6%, p=0.002) compared to controls. Rates of pregnancy-induced hypertension, gestational diabetes, and other complications were also higher in the recurrent abortion group.
Conclusion: Despite achieving successful pregnancy through ICSI, women with a history of recurrent abortions remain at increased risk for adverse pregnancy outcomes, including preterm birth and low birth weight. Close monitoring and management of these high-risk pregnancies is warranted.
Keywords: Recurrent abortion, ICSI, Pregnancy Outcomes